Saint Alexius of Rome (Alexis of Edessa) was an Eastern saint whose veneration was later transplanted to Rome. He is mentioned in an early Syriac legend which recounted that during the episcopate of Bishop Rabbula (412-435), a "Man of God" who lived in Edessa, Mesopotamia as a beggar and shared the alms he received with other poor people. After his death, his family found writings on his body which told them who he was and how he had lived his life of penance from the day of his wedding, for the love of God. He is a Holy Patron of beggars, belt makers, nurses, pilgrims, and travelers. The Eastern Orthodox Church venerates St. Alexius on 17 March.
Relics of Saint Alexius are found in some churches and monasteries in Greece, including the Esphigmenou monastery of Mount Athos and the Dormition of Theotokos Monastery, Boeotia. In Russia, relics of St Alexius are kept in the Alexander Nevsky Lavra in Saint Petersburg. In Cyprus, relics are kept in the Kykkos Monastery. The most precious relic is a large part of the honorable skull of the Saint, which is kept in the monastery of Agia Lavra near Kalavrita, Greece. According to the monastic codex of the monastery, the honorable true skull was donated to the monastery by the Byzantine emperor Manuel II Palaiologos in 1398.